Bioavailability is a crucial concept for the pharmaceutical industry. Determining and testing this value is essential for the entire product development process, starting from early laboratory work, through clinical trials and to registration processes. Absorption is one of the elements that make up the aspect of bioavailability. Due to its fundamental nature, it invariably attracts the attention of scientists and indirectly, consumers themselves. For the active substance to have an effect, it must be absorbed. However, this concept is increasingly being used in the context of dietary supplements. It’s important to verify the product in this respect as well. What is the significance of bioavailability, and why is it worth checking the product in this regard?

Bioavailability tells us what fraction (percentage) of an administered dose in unchanged form is absorbed and then observed in the bloodstream. The resulting value is compared to direct intravenous administration, where 100% of the dose is detected in the blood. If the preparation is administered by a different route, for example orally, we must take into account additional pharmacokinetic processes. Before a tablet or capsule enters the circulation, it must disintegrate, dissolve and then be absorbed. These steps directly result in reducing the dose absorbed into the body. This means that, for example, a tablet containing 200 mg of active substance and bioavailability estimated at 60% will provide us with only 120 mg of the supplemented substance.

we understand that the effectiveness of supplements depends on their bioavailability.
Therefore, we conduct research to evaluate various factors that affect bioavailability, such as: